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Monoclonal Mouse Anti-Human
Glial Fibrillary Acidic Protein (GFAP)
Clone 6F2
Labels astrocytes and some CNS ependymal cells. The antibody is useful in conjunction with Dako monoclonal antibodies to the other intermediate filament proteins, such as cytokeratin (Code M0821), desmin (Code M0760), neurofilament protein (Code M0762), vimentin (Code M7020) and the monoclonal antibody to leucocyte common antigen (Code M0701).
Isotype IgG1, kappa
- Frozen
- Formalin
- HIER
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Glial Fibrillary Acidic Protein, Clone 6F2, is intended for use in immunocytochemistry. The antibody labels glial fibrillary acidic protein (GFAP) and may be a useful tool for the identification of astrocytes and astrocytic cells under normal and pathological conditions (1). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human Glial Fibrillary Acidic Protein, Clone 6F2, is intended for use in immunocytochemistry. The antibody labels glial fibrillary acidic protein (GFAP) and may be a useful tool for the identification of astrocytes and astrocytic cells under normal and pathological conditions (1). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
GFAP from human brain.
Specificity
As demonstrated by immunocytochemistry, the antibody labels GFAP in astrocytes and cells of astrocytic origin (1, 5, 6).
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3.
Clone: 6F2. Isotype: IgG1, kappa.
Mouse IgG concentration: See label on vial.
Clone: 6F2. Isotype: IgG1, kappa.
Mouse IgG concentration: See label on vial.
References
- Leroy K, Duyckaerts C, Bovekamp L, Müller O, Anderton BH, Brion JP. Increase of adenomatosus polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer's disease and in other pathological conditions. Acta Neuropathol 2001;102:1-10.
- Sembritzki O, Hagel C, Lamszus K, Deppert W, Bohn W. Cytoplasmic localization of wild-type p53 in glioblastomas correlates with expression of vimentin and glial fibrillary acidic protein. Neuro-Oncol 2002;4:171-78.
- Ylagan LR, Quinn B. CD44 expression in astrocytic tumors. Mod Pathol 1997;10:1239-46.
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| Product | Size |  | M0761 Culture supernatant
| 1 mL Product No. M076101-2 |
|---|