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Monoclonal Mouse Anti-Human
Plasma Cell
Clone VS38c
Recognizes an intracellular protein of 63 kDa identical with the rough endoplasmic reticulum-associated protein p63. The antibody labels plasma cells strongly, but frequently also labels melanocytic cells, particularly melanoma cells, and a number of epithelial cells, e.g. in mucous glands and tonsils, and secretory epithelia in breast, thyroid and pancreas, both benign and malignant.
The antibody is useful in conjunction with other antibodies for identifying myeloma/plasmacytoma and immunocytoma in tissue biopsies. It is also of value for demonstrating plasmacytic differentiation in B-cell neoplasms.
Isotype IgG1, kappa
- Frozen
- Formalin
- HIER
References
- Turley H, Jones M, Erber W, Mayne K, de Waele M, Gatter K. VS38: a new antibody for detecting plasma cell differentiation in routine sections. J Clin Pathol 1994;47:418-22.
- Schweizer A, Rohrer J, Slot JW, Geuze HJ, Kornfeld S. Reassessment of the subcellular localization of p63. J Cell Sci 1995;108:2477-85.
- Banham AH, Turley H, Pulford K, Gatter K, Mason DY. The plasma cell associated antigen detectable by antibody VS38 is the p63 rough endoplasmic reticulum protein. J Clin Pathol 1997;50:485-9.
- Shanks JH, Bannerjee SS. VS38 immunostaining in melanocytic lesions. J Clin Pathol 1996;49:205-7.
- Delecluse HJ, Anagnostopoulis I, Dallenbach F, Hummel M, Marafioti T, Schneider U, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 1997;89:1413-20.
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
Intended Use
For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Plasma Cell, Clone VS38c, is intended for use in immunocytochemistry. The antibody labels normal and neoplastic plasma cells and may be a useful tool in the identification of myeloma and plasmacytoma in bone marrow or other tissues. Additionally it can assist in distinguishing between lymphoplasmacytoid lymphoma and lymphocytic and follicular lymphoma (1). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Monoclonal Mouse Anti-Human Plasma Cell, Clone VS38c, is intended for use in immunocytochemistry. The antibody labels normal and neoplastic plasma cells and may be a useful tool in the identification of myeloma and plasmacytoma in bone marrow or other tissues. Additionally it can assist in distinguishing between lymphoplasmacytoid lymphoma and lymphocytic and follicular lymphoma (1). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Membrane preparation of MCF-7 AdR cells (breast carcinoma cell line) (2).
Specificity
Anti-Human Plasma Cell, VS38c, was clustered as anti-p63 protein at the Sixth International Workshop and Conference on Human Leucocyte Differentiation Antigens held in Kobe in 1996. The epitope was localized to the C-terminal 419 residues (1).
In Western blotting of cell lysates from plasma and epithelial cell lines under reducing conditions, the antibody labels a band of 64 kDa, corresponding to the p63 protein (1, 2).
In Western blotting of cell lysates from plasma and epithelial cell lines under reducing conditions, the antibody labels a band of 64 kDa, corresponding to the p63 protein (1, 2).
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3.
Clone: VS38c (2). Isotype: IgG1, kappa.
Mouse IgG concentration: see label on vial.
Clone: VS38c (2). Isotype: IgG1, kappa.
Mouse IgG concentration: see label on vial.
References
- Turley H, Banham A, Pulford K, Gatter K. BC28.11. B-cell blind panel: antibodies, recognizing the human p63 protein. In: Kishimoto T, Kikutani H, von dem Borne AEG, Goyert SM, Mason DY, Miyasaka M, et al., editors. Leucocyte typing VI. White cell differentiation antigens. Proceedings of the 6th International Workshop and Conference; 1996 Nov 10-14; Kobe, Japan. New York, London: Garland Publishing Inc.; 1997. p. 245-8.
- Turley H, Jones M, Erber W, Mayne K, de Waele M, Gatter K. VS38: a new monoclonal antibody for detecting plasma cell differentiation in routine sections. J Clin Pathol 1994;47:418-22.
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| Product | Size |  | M7077 Culture supernatant
| 1 mL Product No. M707701-2 |
|---|
Synonym(s) for Antigen
p63 protein