Prostate-Specific Antigen (PSA)
Reacts with prostate secretory and ductal epithelium in normal and neoplastic tissue. The antibody is intended for the immunohistochemical demonstration of a neoplasm being of prostatic origin.
Isotype IgG1, kappa
- Excellent specificity
- High lot to lot consistency
- Optimized for immunohistochemistry (IHC) with validated protocols
- Certified manufacturing facilities guarantee full quality control
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For in vitro diagnostic use.
Monoclonal Mouse Anti-Human Prostate-Specific Antigen, Clone ER-PR8, is intended for use in immunohistochemistry. The antibody labels prostatic epithelium and is a useful tool for the identification of benign and malignant cells of prostatic origin (1, 2). Differential identification is aided by the results from a panel of antibodies. Interpretation must be made within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Purified human prostate-specific antigen.
In Western blotting of PSA purified from seminal plasma the antibody labels bands corresponding to PSA under reducing conditions, whereas no labelling was observed under non-reducing conditions (5). Anti-PSA, Clone ER-PR-8, was included in the ISOBM TD-3 Workshop, which characterized 83 antibodies against prostate-specific antigen. The antibody was confirmed to be useful for the specific immunohistochemical labelling of PSA. The location of the epitope could not be established (6).
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris/HCl, pH 7.2, and containing 15 mmol/L NaN3.
Clone: ER-PR8. Isotype: IgG1, kappa.
Mouse IgG concentration: see label on vial.
- Nap M, van der Kwast TM. Immunohistochemical characterization of 53 monoclonal antibodies to prostate-specific antigen. Tumor Biol 1999 (suppl. 1):20:38-42.
- Papadopoulos I, Sivridis E, Giatromanolaki A, Koukourakis MI. Tumor angiogenesis is associated with MUC1 overexpression and loss of prostate-specific antigen expression in prostate cancer. Clin Cancer Res 2001:7;1533-8.
- Wang TJ, Linton HJ, Sokoloff RL, Grauer LS, Rittenhouse HG, Wolfert RL. Western blotting analysis of antibodies to prostate-specific antigen: specificities for prostate-specific antigen and prostate-specific antigen fragments. Tumor Biol 1999;20 (suppl 1):79-85.
- Stenman U-H, Paus E, Allard WJ, Andersson I, Andrés C, Barnett TR, et al. Summary report of the TD-3 workshop: characterization of 83 antibodies against prostate-specific antigen. Tumor Biol 1999;20 (suppl 1): 1-12.
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Synonym(s) for Antigen
kallikrein 3, PSA