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Monoclonal Mouse Anti-Human
Epithelial Membrane Antigen (EMA)
Clone E29
Labels normal and neoplastic epithelium.
The antibody is very useful together with the monoclonal antibodies to leucocyte common antigen (Code M0701) and cytokeratin (Code M0821), which label cells of lymphoid and epithelial origin, respectively. In the classification of hematolymphoid neoplasms, the antibody labels Reed-Sternberg cells in nodular lymphocyte predominant Hodgkin's lymphoma and neoplastic cells in a subset of anaplastic large cell lymphomas.
Mesothelioma (FFPE) stained with FLEX Anti-EMA, Code IR629/IS629.
Mesothelioma. The malignant mesothelioma cells show a strong staining reaction in membrane and cytoplasm.
Clinical application for IR629/IS629 For identification of tumors of epithelial origin in a wide variety of tissues.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human Epithelial Membrane Antigen, Clone E29, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of epithelial cells in a wide variety of tissues and is a useful tool for the identification of neoplastic epithelia (1). EMA is present on the membrane of secretory epithelia. The absence of EMA staining with monoclonal mouse anti-human epithelial membrane antigen, clone E29 is considered to be strongly suggestive of non-epithelial neoplasia (2). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: E29. Isotype: Ig2a, kappa.
- Cordell J, Richardson TC, Pulford KAF, Ghosh AK, Gatter KC, Heyderman E, et al. Production of monoclonal antibodies against human epithelial membrane antigen for use in diagnostic immunocytochemistry. Br J Cancer 1985;52:347-54.
- Gatter KC, Heryet A, Alcock C, Mason DY. Clinical importance of analyzing malignant tumors of uncertain origin with immunohistological techniques. Lancet 1985; June:1302
- Sloane JP, Ormerod MG. Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumor pathology. Cancer 1981:47:1786-95.
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| Product | Size |  | IR629 Clone E29
| 60 tests, 12 mL Product No. IR62961-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Tonsil | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |
Synonym(s) for Antigen
EMA, MUC-1, MUC1