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Monoclonal Mouse Anti-Human
Inhibin α
Clone R1
Inhibin is a dimeric glycoprotein hormone comprised of an α and a β subunit.
It is produced by ovarian granulosa cells and inhibits the production or secretion of pituitary gonadotropins, particularly follicle-stimulating hormone. The antibody was raised against the terminal 1-32 amino acid sequence of the inhibin α subunit. In abnormal ovarian tissues, inhibin α is a sensitive marker for the majority of sex-cord-stromal tumors.
Granulosa cell tumor (FFPE) stained with FLEX Anti-Inhibin α, Code IR058/IS058.
Granulosa cell tumor. The tumor cells show a moderate to strong granular cytoplasmic staining reaction.
Clinical application for IR058/IS058 For identification of ovarian sex cord and stromal tumors such as granulosa cell tumor. Other positive tumors include complete hydatiform mole, gynandroblastoma and adrenal cortical adenocarcinoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Anti-Human Inhibin α, Clone R1, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody is useful for the identification of ovarian tumors such as ovarian sex cord-stromal tumors (SCST). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: R1 (1). Isotype: IgG2a, kappa.
- Groome N, Hancock J, Betteridge A, Lawrence M, Craven R. Monoclonal and polyclonal antibodies reactive with the 1-32 amino terminal sequence of the alpha subunit of human 32K inhibin. Hybridoma 1990; 9(1):31
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| Product | Size |  | IR058 Clone R1
| 60 tests, 12 mL Product No. IR05861-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Placenta and testis (Leydig and Sertoli cells) | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX+ (Code K8002) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800221-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |