United States of America
LAST PRODUCTS VIEWED
RELATED PRODUCT TAGS
Monoclonal Mouse Anti-Human
Desmin
Clone D33
Labels smooth and striated muscle cells. The antibody works on paraffin-embedded material without pretreament with proteolytic enzymes.
Anti-Desmin, clone D33, is of value in the differential diagnosis of tumors of uncertain origin. It can be used in conjunction with the Dako monoclonal antibodies to the other intermediate filament proteins, such as cytokeratin (Code M0821), glial fibrillary acidic protein (Code M0761), neurofilament protein (Code M0762), vimentin (Code M7020) and the monoclonal antibody to leucocyte common antigen (Code M0701). The excellent performance of Anti-Desmin, D33, is illustrated in reference 1.
- Pollock L, Rampling D, Greenwald SE, Malone M. Desmin expression in rhabdomyosarcoma: influence of the desmin clone and immunohistochemical method. J Clin Pathol 1995;48:535-8.
Uterine leiomyoma (FFPE) stained with FLEX Anti-Desmin, Code IR606/IS606.
Uterine leiomyoma. The majority of the neoplastic cells show a moderate to strong cytoplasmic staining reaction.
Clinical application for IR606/IS606 For identification of smooth and striated muscle cells and reactive mesothelial cells, tumors of muscle origin like leiomyoma and rhabdomyosarcoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human Desmin, Clone D33, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels smooth and striated muscle cells as well as mesothelial cells, and is useful for the identification of rhabdomyosarcomas (1, 2), leiomyomas, (3, 4) and mesotheliomas (5). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
As demonstrated by immunohistochemistry on formalin-fixed, paraffin embedded tissue sections, the antibody cross-reacts with the desmin-equivalent protein in mouse and rat.
Clone: D33. Isotype: IgG1, kappa.
- Chang TK, Li CY, Smithson WA. Immunocytochemical study of small round cell tumors in routinely processed specimens. Arch Pathol Lab Med 1989;113:1343-8.
- Pollock L, Rampling D, Greenwald SE, Malone M. Desmin expression in rhabdomyosarcoma: influence of the desmin clone and immunohistochemical method. J Clin Pathol 1995;48:535-8.
- Miettinen M, Sarlomo-Rikala M, Sobin LH, Lasota J. Esophageal stromal tumors. A clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas. Am J Surg Pathol 2000;24:211-22.
- Oliva E, Young RH, Clement PB, Bhan AK, Scully RE. Cellular benign mesenchymal tumors of the uterus. A comparative morphologic and immunohistochemical analysis of 33 highly cellular leiomyomas and six endometrial stromal nodules, two frequently confused tumors. Am J Surg Pathol 1995;19:757-68.
- Hurlimann J. Desmin and neural marker expression in mesothelial cells and mesotheliomas. Hum Pathol 1994;25:753-7.
- Van Muijen GNP, Ruiter DJ, Warnaar SO. Coexpression of intermediate filament polypeptides in human fetal and adult tissues. Lab Invest 1987;57:359-69.
Check Your Price & Order Online
| Product | Size |  | IR606 Clone D33
| 60 tests, 12 mL Product No. IR60661-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Colon | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |