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Monoclonal Mouse Anti-Human
CD21
Clone 1F8
CD21 is a transmembrane glycoprotein belonging to a family of complement regulatory proteins. It is expressed by follicular dendritic cells (FDC) and mature B cells, as well as by several types of epithelial cells.
The antibody is useful for the identification of structural alterations in the meshwork of FDC, which are frequently found in malignant lymphomas. Furthermore, the antibody may be useful in the differential identification of mature T-cell lymphoma of the angioimmunoblastic subtype.
- Bagdi E, Krenacs L, Krenacs T, Miller K, Isaacson PG. Follicular dendritic cells in reactive and neoplastic lymphoid tissues: a reevaluation of staining patterns of CD21, CD23, and CD35 antibodies in paraffin sections after wet heat-induced epitope retrieval. Appl Immunohistochem Mol Morphol 2001;9:117-24.
- Troxell ML, Schwartz EJ, van de Rijn M, Ross DT, Warnke RA, Higgins JP, et al. Follicular dendritic cell immunohistochemical markers in angioimmunoblastic T-cell lymphoma. Appl Immunohistochem Mol Morphol 2005;13:297-303.
Follicular lymphoma (FFPE) stained with FLEX Anti-CD21, Code IR608/IS608.
Follicular lymphoma (grade I). The follicular dendritic cell network is distinctively stained.
Clinical application for IR608/IS608. For identification of follicular dendritic cells, mature B cells and structural alterations in the meshwork of follicular dendritic cells in some malignant lymphomas like follicular lymphoma and angioimmunoblastic T-cell lymphoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
FLEX Monoclonal Mouse Anti-Human CD21, Clone 1F8, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels follicular dendritic cells and mature B cells and is useful for the identification of structural alterations in the meshwork of follicular dendritic cells, which are frequently found in malignant lymphomas (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
The antibody labels cells or cell lines known to express CD21 (Raji, NC 37, tonsil cells), whereas no labeling is observed in the CD21-negative Jurkat cells (T-cell line) and human erythrocytes (4).
Clone: 1F8 (4). Isotype: IgG1, kappa.
- Bagdi E, Krenacs L, Krenacs T, Miller K, Isaacson PG. Follicular dendritic cells in reactive and neoplastic lymphoid tissues: a reevaluation of staining patterns of CD21, CD23, and CD35 antibodies in paraffin sections after wet heat-induced epitope retrieval. Appl Immunohistochem Molecul Morphol 2001;9:117-24.
- Petzer AL, Schulz TF, Stauder R, Eigentler A, Myones BL, Dierich MP. Structural and functional analysis of CR2/EBV receptor by means of monoclonal antibodies and limited tryptic digestion. Immunology 1988;63:47-53.
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| Product | Size |  | IR608 Clone 1F8
| 60 tests, 12 mL Product No. IR60861-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, Low pH (Code K8005) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800521-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IR750) Positive tissue: Tonsil | 120 tests, 24 mL Product No. IR75066-2 |
| Visualization System | EnVision™ FLEX+ (Code K8002) Use Low pH Target Retrieval Solution | 400-600 tests Product No. K800221-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |
Synonym(s) for Antigen
C3d-receptor, CR2, EBV-receptor