Monoclonal Mouse Anti-Human

CD8

Clone C8/144B

CD8 is a 68 kDa transmembrane glycoprotein expressed as a heterodimer by a majority of thymocytes, and by class I major histocompatibility complex restricted, mature, suppressor/cytotoxic T cells.

The antibody is useful for the identification of cytotoxic/suppressor T cells and their neoplastic counterparts.

Peripheral T-cell lymphoma (FFPE) stained with FLEX Anti-CD8, Code IR623/IS623.

+

Peripheral T-cell lymphoma. Focally, the neoplastic cells show a moderate to strong cytoplasmic and membraneous staining reaction.

Clinical application for IR623/IS623. For identification of cytotoxic/suppressor T cells and their neoplastic counterparts.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Optimized staining performance of both high- and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy

Intended Use
For in vitro diagnostic use.

FLEX Monoclonal Mouse Anti-Human CD8, Clone C8/144B, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels cytotoxic/supressor T cells and is useful for the identification of these cells and their neoplastic counterparts (1). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic peptide corresponding to the 13 C-terminal amino acids of cytoplasmic domain of human CD8α coupled to thyroglobulin (1).
Specificity
SDS-PAGE analysis of immunoprecipitates formed between lysates of 125I-labeled human T lymphoblasts and the antibody shows reaction primarily with a 32 kDa polypeptide corresponding to CD8α (1).
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.

Clone: C8/144B (1). Isotype: IgG1, kappa.
References
  1. Mason DY, Cordell JL, Gaulard P, Tse AGD, Brown MH. Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence. J Clin Pathol 1992:45:1084-8.
ProductSize
For In Vitro Diagnostic UseIR623 Clone C8/144B
Specification Sheet
Safety Data Sheet:
Non-hazard classification statement
60 tests, 12 mL
Product No. IR62361-2

Country selection

Your Dako Account indicates that you are based in , you will be transfered to the web site for

Basket emptied

Your basket was emptied because of the country change.

Country selection

United States of America appears to be your location. To view country specific information on the Dako web site, please accept or change country below.



Get in Touch with Dako in United States of America

  • Pathology Products, Flow Cytometry Products and Specific Proteins
    Dako North America, Inc.

    general@dako.com
    +1 805 566 6655
    +1 805 566 6688

    6392 Via Real
    Carpinteria, CA 93013

  • Flow Cytometry Products
    Fisher Health Care

    +1 800 766 7000
    +1 800 926 1166

    9999 Veterans Memorial Drive
    Houston, TX 77038

Detailed contact information

Submit an Inquiry

How would you like us to follow up?


Cancel

Your session expired

You have been logged out. Log in again to retrieve your Cart.