Monoclonal Mouse Anti-Human

Cytokeratin 5/6

Clone D5/16 B4

Reacts strongly with cytokeratins 5 and 6 and weakly with cytokeratin 4. The antibody does not cross-react with cytokeratins 1, 7, 8, 10, 13, 14, 18 and 19.

It labels mesothelioma, and epithelial basal cells in prostate and tonsil. No reactivity with other mesodermally derived tissues, such as muscle and connective tissues, has been observed. For optimal results on formalin-fixed, paraffin-embedded specimens, heat-induced epitope retrieval using high pH buffer is recommended.

Cytokeratin 5/6 is expressed at low levels in adenocarcinomas, whereas it is present at high levels in epithelioid mesotheliomas, and the antibody is, therefore, very useful in the differentiation between these types of cancer.

Prostate hyperplasia and carcinoma (FFPE) stained with FLEX Anti-Cytokeratin 5/6, Code IR780/IS780.

Prostate hyperplasia and prostate carcinoma. The normal and benign glands show a distinct cytoplasmic staining reaction in the basal cells.

Clinical application for IR780/IS780. For differential diagnosis of poorly differentiated squamous cell carcinoma vs. adenocarcinoma, epithelioid mesothelioma vs. lung carcinoma, ductal hyperplasia vs. ductal carcinoma in situ of the breast, and prostate carcinoma vs. its benign mimics.

Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.

  • Optimized staining performance of both high and low-expression structures
  • Crisp and clear staining with no background
  • Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

For In Vitro Diagnostic UseIR780 Clone D5/16 B4
Safety Data Sheet:
Non-hazard classification statement
60 tests, 12 mL
Product No. IR78061-2

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