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Polyclonal Rabbit Anti-Human
Gastrin
Gastrin is a peptide hormone that is important in the regulation of gastric acid secretion and mucosal cell proliferation.
This antibody labels cells producing gastrin or structural gastrin analogues.
Gastrin-producing tumor spread to the liver (FFPE) stained with FLEX Anti-Gastrin, Code IR519/IS519.
Gastrin-producing tumor spread to the liver. The majority of the neoplastic cells show a moderate granular staining reaction.
Clinical application for IR519/IS519 For identification of gastrin-secreting neuroendocrine tumors.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Link 48
Intended Use
For in vitro diagnostic use.
FLEX Polyclonal Rabbit Anti-Human Gastrin, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels gastrin and is useful for the identification of gastrin secreting neuroendocrine tumors (1, 2). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Polyclonal Rabbit Anti-Human Gastrin, Ready-to-Use (Link), is intended for use in immunohistochemistry together with Autostainer Link instruments. This antibody labels gastrin and is useful for the identification of gastrin secreting neuroendocrine tumors (1, 2). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Synthetic human gastrin-17 non-sulphated form, coupled to bovine serum albumin.
Specificity
The antibody reacts with human non-sulphated and sulphated forms of gastrin-17 as well as gastrin-34, and cross-reacts about 20% with cholecystokinin octapeptide (CCK-8). Traces of contaminating antibodies have been removed by solid-phase absorption with bovine plasma proteins.
The specificity of the antibody has been ascertained as follows:
Crossed immunoelectrophoresis: No precipitation arch appears when using 12.5 µL concentrated antibody per cm2 gel area against 2 µL of human plasma or 2 µL bovine serum. Staining: Coomassie Brilliant Blue.
The specificity of the antibody has been ascertained as follows:
Crossed immunoelectrophoresis: No precipitation arch appears when using 12.5 µL concentrated antibody per cm2 gel area against 2 µL of human plasma or 2 µL bovine serum. Staining: Coomassie Brilliant Blue.
Reagent Provided
Ready-to-use polyclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
References
- Perkins PL, McLeod MK, Jin L, Fukuuchi A, Cho KJ, Thompson NW, et al. Analysis of gastrinomas by immunohistochemistry and in situ hybridization histochemistry. Diag Mol Path 1992;1:155-4.
- Wang G, Yao J, Worah S, White J, Luna R, Wu TT et al. Comparison of genetic alterations in neuroendocrine tumors: frequent loss og chromosome 18 in ileal carcinoid tumors. Modern Path 2005;18: 1079-87.
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| Product | Size |  | IR519
| 60 tests, 12 mL Product No. IR51961-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IR600) Positive tissue: Pyloric antrum of the stomach | 120 tests, 24 mL Product No. IR60066-2 |
| Visualization System | EnVision™ FLEX (Code K8000) Use High pH Target Retrieval Solution | 400-600 tests Product No. K800021-2 |
| Counterstain | Hematoxylin (Link) (Code K8008) Non-aqueous, permanent mounting medium is required | 3 x 45 mL, 400-600 tests Product No. K800821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |