United States of America
LAST PRODUCTS VIEWED
RELATED PRODUCT TAGS
Monoclonal Mouse Anti-Human
Neurofilament Protein
Clone 2F11
Neurofilaments belong to the family of intermediate filaments and are structural elements of the neuronal cytoskeleton in an interconnection with actin microfilaments, microtubules and other intermediate filaments.
This antibody labels neurons (axons) of the central and peripheral nervous system, and is useful for the identification of tumors with neuronal differentiation.
Merkel cell carcinoma (FFPE) stained with FLEX Anti-Neurofilament Protein, Code IR607/ IS607.
Merkel cell carcinoma. A strong heterogeneous, cytoplasmic and dot-like staining reaction is seen in the neoplastic cells.
Clinical application for IR607/IS607 For identification of neurons (axons) of the central and peripheral nervous system, and for identification of tumors with neuronal differentiation as well as Merkel cell carcinoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human Neurofilament Protein, Clone 2F11, Ready-to-Use (Dako Autostainer/ Autostainer Plus), is intended for use in immunohistotochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels neurons (axons) of the central and peripheral nervous system (1, 2), and is useful for the identification of tumors with neuronal differentiation (1, 3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
In immunohistochemistry, the antibody specifically labels neuronal cells (6).
Clone: 2F11 (6). Isotype: IgG1, kappa.
- Diepholder HM, Schwechheimer K, Mohadjer M, Knoth R, Volk B. A clinicopathologic and immunomorphologic study of 13 cases of ganglioglioma. Cancer 1991;68:2192-2201.
- Luider TM, van Dommelen MW, Tibboel D, Meijers JH, Ten Kate FJ, Trojanowski JQ, et al. Differences in phosphorylation state of neurofilament proteins in ganglionic and aganglionic bowel segments of children with Hirschsprung's disease. J Pediatr Surg 1992; 27: 815-9.
- Van Muijen GNP, Ruiter DJ, Warnaar SO. Intermediate filaments in Merkel cell tumors. Hum Pathol 1985;16:590-5.
- Klück P, van Muijen GNP, van der Kamp AWM, Tibboel D, van Hoorn WA, Warnaar SO, et al. Hirschsprung's disease studied with monoclonal antineurofilament antibodies on tissue sections. Lancet 1984;i:652-4.
Check Your Price & Order Online
| Product | Size |  | IS607 Clone 2F11
| 30 tests, 6 mL Product No. IS60730-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Colon | 60 tests, 12 mL Product No. IS75061-2 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |