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Polyclonal Rabbit Anti-Human
Alpha-1-Fetoprotein
Alpha-1-fetoprotein (AFP) is a 70 kDa glycoprotein, synthesized by the cells of the embryonic yolk sac, fetal liver and fetal intestinal tract.
Expression of AFP has been demonstrated in many hepatocellular carcinomas and in gonadal and extragonadal germ cells tumors, including yolk sac tumors. The antibody may be useful for the identification of non-neoplastic and neoplastic liver diseases, yolk sac tumors and mixed germ cell tumors.
Yolk sac tumor (FFPE) stained with FLEX Anti-Alpha-1-Fetoprotein, Code IR500/IS500.
Yolk sac tumor. The neoplastic cells show a focal and distinct cytoplasmic staining reaction.
Clinical application for IR500/IS500. Primarily for identification of hepatocellular carcinoma, hepatoid tumor, and germ cell tumors of the testis and ovary such as yolk sac tumor and embryonal carcinoma.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Polyclonal Rabbit Anti-Human Alpha-1-Fetoprotein, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. Antibodies to Alpha-1-Fetprotein may be useful for the identification of non-neoplastic and neoplastic liver disease, yolk sac tumors and mixed germ cell tumors (1-3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
In indirect ELISA no significant reaction is observed with normal human plasma.
As demonstrated by rocket immunoelectrophoresis, the antibody cross-reacts with the AFP-equivalent protein in cat and wildebeest (8).
- Jacobsen GK, Jacobsen M. Alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) in testicular germ cell tumours. A prospective immunohistochemical study. Acta Path Microbiol Immunol Scand Sect A 1983; 91:165-76.
- Kodama T, Kameya T, Hirota T, Shimosato Y, Ohkura H, Mukojima T, et al. Production of alpha-fetoprotein, normal serum proteins, and human chorionic gonadotropin in stomach cancer: Histologic and immunohistochemical analyses of 35 cases. Cancer 1981; 48:1647-55.
- Perrone T, Steeper TA, Dehner LP. Alpha-fetoprotein localization in pure ovarian teratoma. An immunohistochemical study of 12 cases. Am J Clin Pathol 1987; 88:713-17.
- Hau J, Nilsson M, Skovgaard-Jensen H-J, de Souza A, Eriksen E, Wandall LT. Analysis of animal serum proteins using antisera against human analogous proteins. Scand J Lab Anim Sci 1990; 17:3-7.
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| Product | Size |  | IS500
| 30 tests, 6 mL Product No. IS50030-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Rabbit (Code IS600) Positive tissue: Embryonal carcinoma | 60 tests, 12 mL Product No. IS60061-2 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |
Synonym(s) for Antigen
AFP