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Monoclonal Mouse Anti-Human
Hepatocyte
Clone OCH1E5
The antigen recognized by this antibody is present in normal human hepatocytes and is conserved in a majority of hepatocellular carcinomas (1).
The antibody does not label other tumors, except for some rare tumors of gastrointestinal origin.
References
- Minervini MI, Demetris AJ, Lee RG, Carr BI, Madariaga J, Nalesnik MA. Utilization of hepatocyte-specific antibody in the immunocytochemical evaluation of liver tumors. Mod Pathol 1997;10:686-92.
Hepatocellular carcinoma (FFPE) stained with FLEX Anti-Hepatocyte, IR624/IS624.
Hepatocellular carcinoma. The neoplastic cells show a strong and homogeneous granular cytoplasmic staining reaction.
Clinical application for IR624/IS624 For differential diagnosis of hepatocellular tumors, clear cell hepatocellular carcinomas from other clear cell malignancies.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
Intended Use
For in vitro diagnostic use.
FLEX Monoclonal Mouse Anti-Human Hepatocyte, Clone OCH1E5, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels hepatocytes and is useful for the differential diagnosis of hepatocellular tumors in general (1), for the differentiation of clear cell hepatocellular carcinomas from other clear cell malignancies (2), and for the distinction of hepatoblastoma, especially the embryonal type, from other small, round-cell tumors of childhood (3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
FLEX Monoclonal Mouse Anti-Human Hepatocyte, Clone OCH1E5, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody labels hepatocytes and is useful for the differential diagnosis of hepatocellular tumors in general (1), for the differentiation of clear cell hepatocellular carcinomas from other clear cell malignancies (2), and for the distinction of hepatoblastoma, especially the embryonal type, from other small, round-cell tumors of childhood (3). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Immunogen
Formalin-fixed, failed human allograft liver that was mechanically disrupted (4).
Specificity
The antibody labels an antigen that seems to be localized to the mitochondrial fraction of liver homogenates (4).
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Clone: OCH1E5 (4). Isotype: IgG1, kappa.
Clone: OCH1E5 (4). Isotype: IgG1, kappa.
References
- Minervini MI, Demetris AJ, Lee RG, Carr BI, Madariaga J, Nalesnik MA. Utilization of hepatocyte-specific antibody in the immunocytochemical evaluation of liver tumors. Mod Pathol 1997; 10:686-92.
- Murakata LA, Ishak KG, Nzeako UC. Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. Mod Pathol 2000;13:874-81.
- Fasano M, Theise ND, Nalesnik M, Goswami S, Garcia de Davila MT, Finegold MJ, et al. Immunohistochemical evaluation of hepatoblastomas with use of the hepatocyte-specific marker, hepatocyte paraffin 1, and the polyclonal anti-carcinoembryonic antigen. Mod Pathol 1998;11:934-8.
- Wennerberg AE, Nalesnik MA, Coleman WB. Hepatocyte paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors. Am J Pathol 1993; 143:1050-4.
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| Product | Size |  | IS624 Clone OCH1E5
| 30 tests, 6 mL Product No. IS62430-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Liver | 60 tests, 12 mL Product No. IS75061-2 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | FLEX IHC Microscope Slides (Code K8020) Recommended for greater adherence | 5 x 100 slides Product No. K802021-2 |
Synonym(s) for Antigen
Hep Par, Hep Par 1, Hep Par-1