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Monoclonal Mouse Anti-Human
Smooth Muscle Myosin Heavy Chain
Clone SMMS-1
Reacts with smooth muscle cells and myoepithelial cells, but not with myofibroblasts.
The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature which may distinguish benign breast lesions and carcinoma in situ from invasive tumors.
Breast hyperplasia (FFPE) stained with FLEX Anti-Myosin Heavy Chain (Smooth Muscle), Code IR066/IS066.
Breast hyperplasia. The myoepithelial cells around the ducts and the smooth muscle cells in the vessel walls show a strong staining reaction.
Clinical application for IR066/IS066 For identification of myoepithelial cells in the breast, and for identification of smooth muscle neoplasm.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
- Optimized staining performance of both high- and low-expression structures
- Crisp and clear staining with no background
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Autostainer Plus
FLEX Monoclonal Mouse Anti-Human Smooth Muscle Myosin Heavy Chain, Clone SMMS-1, Ready-to-Use (Dako Autostainer/Autostainer Plus), is intended for use in immunohistochemistry together with Dako Autostainer/Autostainer Plus instruments. This antibody is useful for the identification of breast myoepithelial cells. Myoepithelial cells are generally present in breast hyperplasia and ductal carcinoma in situ, and absent in invasive breast carcinoma (1-5). The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Clone: SMMS-1 (1). Isotype: IgG1, kappa.
- Frid MG, Shekhonin B, Koteliansky VE, Glukhova MA. Phenotypic changes of human smooth muscle cells during development: Late expression of heavy caldesmon and calponin. Dev Biol 1992; 153:185-93.
- Glukhova MA, Frid MG, Koteliansky VE. Developmental changes in expression of contractile and cytoskeletal proteins in human aortic smooth muscle. J Biol Chem 1990; 265(22):13042-6.
- Borrione AC, Zanellato AMC, Scabbaoueco G, Pauletto P, Sartore S. Myosin heavy-chain isoforms in adult and developing rabbit vascular smooth muscle. Eur J Biochem 1989; 183:413-7.
- Sartore S, De Marzo N, Borrione AC, Zanellato AMC, Saggin L, Fabbri L, Schiffino S. Myosin heavy-chain isoforms in human smooth muscle. Eur J Biochem 1989; 179:79.
- Lazard D, Sastre X, Frid MG, Glukhova MA, Thiery J, Koteliansky VE. Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci USA 1993; 90:999-1003.
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| Product | Size |  | IS066 Clone SMMS-1
| 30 tests, 6 mL Product No. IS06630-2 |
|---|
RECOMMENDED COMPANION PRODUCTS
| Step | Product | Size |
|---|---|---|
| Pre-treatment | EnVision™ FLEX Target Retrieval Solution, High pH (Code K8004) 3-in-1 procedure using PT Link | 3 x 30 mL Product No. K800421-2 |
| Antibody Dilution | Ready-to-use / Prediluted | |
| Negative Control | FLEX Negative Control, Mouse (Code IS750) Positive tissue: Uterus and appendix | 60 tests, 12 mL Product No. IS75061-2 |
| Visualization System | EnVision™ FLEX (Code K8010) Use High pH Target Retrieval Solution | 400-600 tests Product No. K801021-2 |
| Counterstain | Hematoxylin (Dako Autostainer/Autostainer Plus) (Code K8018) Non-aqueous, permanent mounting medium is required | 10 x 13 mL, 400-600 tests Product No. K801821-2 |
| Glass Slides | Silanized Slides (Code S3003) Recommended for greater adherence Alternative is FLEX IHC Microscope Slides (Code K8020) | 100 slides Product No. S300330-2 |