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Monoclonal Rabbit Anti-Human
Estrogen Receptor α
Clone SP1
This monoclonal rabbit antibody reacts with human estrogen receptor α (ER α).
Estrogens have been found to be preferentially concentrated in the estrogen target organs of animals and in human breast cancers, and it is well documented that the mitogenic effects of estrogen are mediated by ER. Historical studies have shown that ER status is correlated with untreated outcome (i.e. prognostic for well-differentiated invasive breast cancer) and with response to anti-hormonal therapy, e.g. tamoxifen (1). The antibody may be used in the semi-quantitative detection of human estrogen receptor in tissue sections of human breast cancer by immunohistochemistry.
- Elledge RM, Fuqua SAW. Chapter 31: Estrogen and Progesterone Receptors. In: Diseases of the Breast. Harris JR, et al. eds. Philadelphia: Lippincott Williams & Wilkins 2000:471-85.
Breast ductal carcinoma with positive estrogen receptor expression. Neoplastic cells show a distinct nuclear staining reaction.
Clinical application for IR151/IS151 For detection of estrogen receptor status in breast cancer.
Disclaimer: Due to variances among color computer monitors, the colors you see on your screen may not be the exact colors of the stain. The image you see should be considered close renditions to the actual stain.
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| Product | Size |  | IS151 Clone SP1
| 30 tests, 6 mL Product No. IS15130-2 |
|---|